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In twelve month clinical trials using Orlistat, 35.5% to 54.8% of test subjects saw a 5% decrease of overall total body mass. Although not all among the mass lost was necessarily body body weight. About 16.4% to 24.8% saw a 10% reduction in overall weight. When the utilization of the drug was halted, a significant number of test subjects gained weight back. They gained back about 35% of the weight they had lost. Alli has about 50 % the dose of Orlistat, and comes at 60mg per supplement.

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